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I have been using Prograf for 4 years now. 1 mg in the AM and 1 mg in PM. Last year or 3rd year into this treatment I had 2 episodes with squamous cell carcinoma, which were both removed.
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Usually, generic products become available once the patent protections afforded to the original manufacturer have expired.
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I took the lowest possible dose of Prograf and all is well now.

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Most of the time, these side effects are not bothersome enough to cause patients to discontinue the use of Altosec.

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Lower tacrolimus trough levels are associated with subsequently higher acute rejection risk during the first 12 months after kidney transplantation.

Results: The new rack system proved, that, even when a larger number of patient samples have to be extracted concomitantly, sample exchange by mistake is totally avoided, and that samples can be vortexed, incubated and centrifuged in large batches (up to 40) without the need to touch secondary sample tubes during all processes: All these steps may be performed without the need to label these secondary precipitation tubes, nor the ARCHITECT analyzer tertiary sample tubes.

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Then the observed serum levels on the new regimen (other occasions) were compared with the predicted ones using the mean prediction error (MPE%) as a measure of bias, the mean absolute deviation from MPE and the mean absolute prediction error (MAPE%) as measures of precision.

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Finally, I will recommend much more stringent regulatory action than has been proposed by the FDA.

Conclusion: With the exception of digoxin, tobramycin, and vancomycin, good overall method comparability could be demonstrated indicating an improved assay harmonization for therapeutic drug monitoring.

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Each transplant recipient is different and requires a personalized treatment approach.

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